What Is Carboplatin Powder?
Carboplatin Powder(CAS No. 41575-94-4) is a platinum-based compound classified within the antineoplastic API category. It is supplied as a pharmaceutical active ingredient or research-grade material for use in formulation development.
As a second-generation platinum derivative, carboplatin has been characterized in the published literature by its pharmacological profile relative to earlier platinum agents. Its development was informed by efforts to explore alternative safety and tolerability characteristics, with documented differences in renal and gastrointestinal effects compared to certain other platinum-based compounds.
For formulation development, regulatory submissions, or research applications, please consult your internal technical and regulatory teams to ensure alignment with applicable regional requirements.
Chemical & Physical Characteristics
- Chemical name: Carboplatin
- IUPAC name: cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)
- Molecular formula: C₆H₁₂N₂O₄Pt
- Molecular weight: 371.25 g/mol
- CAS number: 41575-94-4
- Appearance: White to off-white crystalline powder
- Solubility: Slightly soluble in water
- pH (solution): Typically neutral to slightly acidic
- Stability: Sensitive to light and strong oxidizing/reducing agents
Carboplatin contains a platinum metal center, which is responsible for its anticancer activity.
Product Specifications
As an injectable anticancer API, specifications are exceptionally stringent, focusing on purity, impurity profiling, and sterility assurance.
|
Parameter |
Specification |
|
Assay (HPLC) |
98.0% - 102.0% (on anhydrous, solvent-free basis) |
|
Impurity Profile (HPLC) |
Individual Known Impurities: Strict limits for Cisplatin (genotoxic), Transplatin, Carboplatin dimer, CBDCA-related impurities. Total Impurities: ≤ 2.0%. |
|
Platinum Content (AAS) |
51.0% - 53.5% of theory (~52.3%) |
|
Bacterial Endotoxins |
< 1.0 EU/mg (or per vial spec for final product) |
|
Sterility |
Must comply with sterility test (for API intended for sterile processing). |
|
Water Content (KF) |
≤ 0.5% |
|
Storage & Shelf Life |
24-36 months in original sealed container, protected from light and moisture at controlled room temperature. |
Mechanism of Action & Pharmacology
Carboplatin Powder(CAS No. 41575-94-4) is a cell cycle non-specific alkylating agent. Its primary mechanism involves the formation of cytotoxic platinum-DNA adducts.
Activation: In the low-chloride intracellular environment, the labile cyclobutanedicarboxylate (CBDCA) ligand is displaced by water molecules, generating reactive aquated species.
DNA Binding: These activated platinum complexes covalently bind to purine bases (primarily N7 of guanine and adenine) in DNA, forming intrastrand and interstrand cross-links. This disrupts DNA structure and function, inhibiting replication and transcription.
Cellular Consequence: The DNA damage triggers complex cellular signaling pathways, ultimately leading to apoptosis (programmed cell death) in rapidly dividing cells, such as cancer cells.
Key Pharmacokinetic Feature: Unlike cisplatin, carboplatin's reactivity is lower, and its clearance is primarily renal, closely correlated with glomerular filtration rate (GFR). This allows for precise dosing using the Calvert formula (Dose = Target AUC x [GFR + 25]), minimizing toxicity.
Why Choose TNJONE Carboplatin Powder?
TNJONE Carboplatin powder(CAS No. 41575-94-4) is a high-purity, pharmaceutical-grade active ingredient widely used in research and pharmaceutical applications. Manufactured under strict GMP standards, each batch delivers consistent quality with comprehensive documentation, including COA, stability data, and regulatory support files. Trusted by researchers and pharmaceutical manufacturers for reliable performance and consistent sourcing, we offer flexible supply from R&D quantities to commercial volumes, backed by responsive technical support and dependable global logistics. Contact us today to request specifications or samples.
TNJONE Products are designed for research and industrial use only. Not intended for clinical or medical purposes.
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