Palmitoyl Tetrapeptide-7(Palmitoyl) Powder CAS 221227-05-0

Palmitoyl Tetrapeptide-7 powder (CAS: 221227-05-0) is a peptide chain composed of four amino acids (hence the name "tetrapeptide"), with a palmitoyl group attached to one end. This palmitoyl group acts like a "key," helping the peptide molecule penetrate the skin's stratum corneum more easily and reach its target site. It is a biomimetic ingredient, mimicking a fragment of laminin-5, an important structural protein in the dermis responsible for maintaining skin firmness and elasticity.

Anti-Aging and Anti-Wrinkle
By stimulating dermal fibroblasts to synthesize collagen, laminin, and glycosaminoglycans, it strengthens the skin's support structure from within. It improves skin elasticity and firmness, smooths fine lines and wrinkles, and makes facial contours more defined.

Soothing for Sensitive Skin
It inhibits the release of pro-inflammatory cytokines, reducing micro-inflammation in the skin at its source.It relieves redness, burning, and other discomforts. It also helps repair the damaged skin barrier.

Improved Skin Tone and Radiance
It reduces the risk of post-inflammatory hyperpigmentation and, by improving dermal health, makes the skin look more translucent, plump, and radiant. It evens out skin tone, brightens dullness, and creates a "healthy skin base."

Eye Area Care
It improves fine lines and dryness around the eyes, and reduces puffiness and dark circles.

Serum
Serums typically contain a higher concentration of active ingredients, and their small molecular size and good penetration allow them to maximize the efficacy of peptide components. They are commonly found in anti-aging and soothing/repairing serums.

Face Cream/Lotion
As part of daily skincare, these provide continuous repair and anti-aging benefits. They are often found in high-end anti-wrinkle lines or products specifically for sensitive skin.

Eye Cream/Eye Serum
Formulated specifically for eye area concerns, the concentration and texture are adjusted accordingly.

Single-Use Serum Ampoules
High-concentration, high-activity products used for intensive treatment or emergency repair.

Face Mask
During application, masks create a sealed environment to promote ingredient penetration, providing immediate and short-term soothing, hydrating, and brightening effects.

Recommended Formulation Design

• pH range: 5.0-7.0, to ensure peptide stability.
• Compatible ingredients:Vitamin C derivatives (to enhance collagen synthesis), hyaluronic acid (to improve hydration), niacinamide (for synergistic anti-inflammatory effects).
• Process control: Avoid high temperatures (>50℃) or prolonged stirring to prevent peptide chain degradation.

Compatibility Restrictions

• Strongly acidic environment (pH<4): May lead to hydrolysis of the palmitoyl group, reducing activity.
• Metal ions (such as Fe³⁺, Cu²⁺): Can trigger oxidation reactions; chelating agents (such as EDTA disodium) should be added.
• High concentration ethanol (>10%): Damages peptide structure; it is recommended to add in stages or use a lower concentration solvent.

Whether you are developing advanced cosmeceuticals or conducting mechanistic studies, TNJONE Palmitoyl Tetrapeptide-7 offers the stability and potency your applications require.

Contact us for a COA, MSDS, Tech Data Sheet, and Tips for Formulation.

Products are for research use only. Not for human use. We do not sell to individuals.

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