Di-tert-butyl Dicarbonate Powder CAS 1007089-84-0

Di-tert-butyl dicarbonate Powder, also widely known as Di-tert-butyl dicarbonate or Boc anhydride, is a high-purity organic carbonate compound extensively used as a protecting reagent in organic synthesis. With CAS No. 24424-99-5, this compound plays a critical role in pharmaceutical intermediates, peptide synthesis, fine chemicals, and advanced material research.

In modern chemical manufacturing, protecting functional groups during multi-step synthesis is essential for reaction selectivity, yield optimization, and impurity control. Di-tert-butyl dicarbonate Powder is specifically valued for its ability to introduce the Boc (tert-butyloxycarbonyl) protecting group under mild reaction conditions, offering excellent compatibility with a wide range of substrates.

Due to its high reactivity, stability under controlled conditions, and predictable deprotection behavior, Di-tert-butyl dicarbonate (CAS: 24424-99-5) has become a preferred choice for global manufacturers involved in APIs, polypeptides, amino acid derivatives, and fine chemical intermediates.

Our Di-tert-butyl dicarbonate Powder is produced under strict quality control systems, ensuring consistent purity, reliable batch-to-batch performance, and compliance with international chemical supply standards. It is suitable for use in R&D laboratories, pilot-scale production, and industrial-scale synthesis.

Di-tert-butyl dicarbonate Powder (CAS: 24424-99-5) is a versatile and critical reagent with a primary function: the protection of amines. Its applications span across several high-value industries:
1.Peptide Synthesis (Solid-Phase & Solution-Phase): This is the quintessential application for Boc₂O. In the classic Boc-SPPS (Solid-Phase Peptide Synthesis) strategy, Di-tert-butyl dicarbonate is used to protect the α-amino group of each amino acid before coupling. Its orthogonal stability compared to the Fmoc group allows for complex peptide assembly. The Boc group is stable to base and hydrogenolysis but is cleanly removed with acids like trifluoroacetic acid (TFA), enabling sequential deprotection and chain elongation.

2.Pharmaceutical Intermediates & API Manufacturing: The synthesis of numerous small-molecule drugs involves amine intermediates that require temporary protection. Di-tert-butyl dicarbonate provides a highly reliable method for this, ensuring reactions can proceed at other functional sites without interference. It is instrumental in creating precursors for antibiotics, antiviral agents, kinase inhibitors, and complex alkaloids.

3.Combinatorial Chemistry & Library Synthesis: For generating diverse libraries of compounds for high-throughput screening in drug discovery, the robust and well-understood chemistry of the Boc group facilitated by Boc₂O is invaluable. It allows for the automated, sequential protection and deprotection cycles necessary to build vast arrays of structurally related molecules.

4.Fine Chemical and Agrochemical Synthesis: Beyond pharmaceuticals, the need for selective amine protection arises in the synthesis of advanced dyes, photographic chemicals, ligands for catalysis, and sophisticated agrochemicals. Di-tert-butyl dicarbonate offers a high-yielding, predictable pathway for these syntheses.

5.Bioconjugation and Materials Science: In developing antibody-drug conjugates (ADCs) or functionalized polymers, amines on lysine residues or polymer chains often require specific modification. The Boc group, installed using Boc₂O, can act as a temporary mask, allowing for selective conjugation at other sites before being removed to reveal the native amine for further
functionalization.

To meet the needs of international buyers, Di-tert-butyl dicarbonate (CAS: 24424-99-5) is packaged in secure, moisture-resistant containers suitable for long-distance transportation.
Flexible options include:
Small research quantities
Bulk industrial packaging
OEM labeling upon request

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