Fusidic Acid Powder CAS 6990-06-3

Fusidic Acid Powder is a steroid-like antibiotic primarily used for the treatment of Gram-positive bacterial infections, especially those caused by Staphylococcus aureus, including many strains resistant to other antibiotics. Fusidic acid powder is supplied as a pharmaceutical raw material (API) or research-grade compound for use in drug manufacturing, formulation development, and scientific studies.

Fusidic Acid Powder is a lipophilic compound, which contributes to its good penetration into skin and soft tissues, making it especially effective in topical formulations.

Class & Unique Feature: A bacteriostatic antibiotic belonging to the fusidane class. It is the only clinically available member of this class.

Primary Mechanism: It specifically inhibits bacterial protein synthesis by binding to elongation factor G (EF-G) in complex with GDP on the ribosome. This binding stabilizes the ribosome-EF-G-GDP complex after translocation, preventing its dissociation and thereby halting the protein synthesis cycle.

Spectrum of Activity: Primarily active against Gram-positive bacteria, with exceptional potency against:

Staphylococcus aureus (including Methicillin-Resistant S. aureus - MRSA and β-lactamase-producing strains).
Staphylococcus epidermidis.
Corynebacterium spp..
Clostridium spp..
Has variable activity against Neisseria, Moraxella, and Bacteroides fragilis. It is inactive against most Gram-negative bacteria due to poor penetration of the outer membrane.

Resistance: Chromosomal mutations in the fusA gene (encoding EF-G) can lead to resistance. Plasmid-mediated resistance (fusB, fusC, fusD) via protection proteins is also common, leading to the recommendation to use it in combination therapy (e.g., with rifampicin) for serious systemic infections to prevent resistance emergence.

Fusidic Acid Powder is a valuable therapeutic agent, particularly for its anti-staphylococcal activity.

1.Topical Therapy (Primary Use): Treatment of superficial skin and eye infections caused by susceptible organisms.
Skin: Impetigo, infected eczema, folliculitis, furuncles, wounds, and burns.
Eye: Bacterial conjunctivitis, blepharitis (as eye drops or ointment).

2.Systemic Therapy: Reserved for serious infections, usually with its sodium salt (Sodium Fusidate) administered orally or intravenously.
Osteomyelitis and septic arthritis (especially staphylococcal).
Deep-seated soft tissue infections.
Device-related infections (e.g., prosthetic joint infections).
Crucially, it is almost always used in combination with another anti-staphylococcal agent (e.g., rifampicin, flucloxacillin) to prevent resistance.

3.Special Niche: A drug of choice for infections caused by MRSA when other options are limited or intolerable.

Fusidic Acid Powder is a specialized antibacterial API with strong activity against Gram-positive pathogens, particularly Staphylococcus species. Its unique mechanism of action, effectiveness against resistant strains, and excellent suitability for topical formulations make it an important raw material in dermatological and anti-infective pharmaceuticals.

TNJONE Fusidic Acid Powder(CAS NO. 6990-06-3) is the trusted choice for procurement professionals seeking a reliable, high-quality source of this essential antibacterial agent. Manufactured in GMP-certified facilities, every batch meets USP and EP purity standards with strict batch-to-batch consistency, supported by comprehensive documentation including COA, stability data, and regulatory files to streamline your quality control and market access processes. With flexible supply options ranging from research-scale to commercial volumes backed by dependable global logistics, we deliver the quality, traceability, and regulatory confidence that pharmaceutical manufacturers and research organizations require.

TNJONE Products are designed for research and industrial use only. Not intended for clinical or medical purposes.

Hot Tags: fusidic acid powder cas 6990-06-3, China fusidic acid powder cas 6990-06-3 manufacturers, suppliers, factory, api, Diphenhydramine Hydrochloride Powder, Empagliflozin Powder CAS 864070 44 0, Heparin sodium Powder, Minoxidil Powder, Shikimic acid Powder